DNA endonuclease RBBP8 (IPR033594)

Short name: RBBP8

Overlapping homologous superfamilies


Family relationships


Retinoblastoma-binding protein 8 (RBBP8), also known as CtIP, is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [PMID: 17965729, PMID: 25558984]. CtIP interacts with the BRCA1 tumour suppressor [PMID: 23712259]. BRCA1 and CtIP are required to recruit Dna2 at DSBs in homologous recombination, ensuring robust DSB resection [PMID: 25909997]. CtIP it is not a tumuor suppressor itself, instead, it can promote tumourigenesis. This is probably related to its role in the formation of chromosomal rearrangements through the microhomology-mediated end joining (MMEJ) pathway, a relatively error-prone pathway of DSB repair [PMID: 27058754].

GO terms

Biological Process

GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
GO:0000724 double-strand break repair via homologous recombination

Molecular Function

GO:0004519 endonuclease activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.