Family

Inactive tyrosine-protein kinase 7 (IPR033592)

Short name: PTK7

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Protein tyrosine kinase 7 (PTK7) is an inactive tyrosine kinase involved in Wnt signalling (both the non-canonical and the canonical Wnt signalling pathway) [PMID: 24431302, PMID: 21132015, PMID: 23533179]. This receptor tyrosine kinase-like molecule can act as an important regulator of planar cell polarity (PCP) through a beta-catenin-independent pathway that coordinates the cell orientation and movement within the plane of a tissue [PMID: 15229603, PMID: 24703874, PMID: 24703875]. PTK7 is required for multiple developmental processes, including convergent extension, neural tube closure and PCP in the auditory sensory epithelium.

PTK7 contains seven extracellular immunoglobulin (Ig)-like domains, a transmembrane domain, and a catalytically inactive kinase domain where the ATP-binding motif is mutated [PMID: 7478540]. Altered PTK7 expression has been observed in several cancers [PMID: 9185712, PMID: 25962058, PMID: 24987951].

GO terms

Biological Process

GO:0016055 Wnt signaling pathway
GO:0060026 convergent extension
GO:0001736 establishment of planar polarity

Molecular Function

GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER