Patatin-like phospholipase domain-containing protein (IPR033562)

Short name: PLPL

Overlapping homologous superfamilies

Family relationships


This entry includes patatin-like phospholipase domain-containing proteins 1-5 (PNPLA1-5) from humans and Atgl-1 from Caenorhabditis elegans. They are a group of lipid hydrolases.

Atgl-1 may play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion [PMID: 19052547, PMID: 20176933, PMID: 24120942, PMID: 25202121, PMID: 26083785, PMID: 26098762].

Human PNPLA1 plays a role in glycerophospholipid metabolism [PMID: 22246504]. PNPLA2 catalyses the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets [PMID: 15550674]. PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities [PMID: 15364929].

GO terms

Biological Process

GO:0016042 lipid catabolic process

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.