Caspase recruitment domain-containing protein 11 (IPR033538)

Short name: CARD11

Overlapping homologous superfamilies


Family relationships



The caspase recruitment domain (CARD) is a homotypic protein interaction module that participates in apoptosis signalling. This entry represents CARD11, which is a large multidomain scaffold protein that functions as upstream activator of NF-kappaB signalling [PMID: 11278692]. It forms a CBM complex with BCL10 and MALT1. The CBM complex links AgR (antigen receptor) triggering to NF-kappaB activation [PMID: 25087226]. Its activity is controlled by an Inhibitory Domain (ID) [PMID: 26884334].

Mutations in the CARD11 gene cause B-cell expansion with NFKB and T-cell anergy (BENTA) [PMID: 23129749] and Immunodeficiency 11 (IMD11) [PMID: 23374270].

GO terms

Biological Process

GO:0051092 positive regulation of NF-kappaB transcription factor activity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.