Receptor-type tyrosine-protein phosphatase-like N/N2 (IPR033522)

Short name: IA-2/IA-2_beta

Overlapping homologous superfamilies


Family relationships



This entry includes mammalian receptor-type tyrosine-protein phosphatase-like N and N2, also known as islet antigen 2/2 beta (IA-2 and IA-2 beta). They are dense core vesicle (DCV) transmembrane proteins that play a role in vesicle-mediated secretory processes. They are major autoantigens in type 1 diabetes and are required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation [PMID: 21732083, PMID: 24843546]. This entry also includes some uncharacterised proteins from invertebrates.

Despite showing high homology to protein tyrosine phosphatases (PTPases), IA-2 has been shown to lack intrinsic enzyme activity [PMID: 8878556].

GO terms

Biological Process

GO:0035773 insulin secretion involved in cellular response to glucose stimulus

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030141 secretory granule

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.