PLAA/Doa1/Lub1 (IPR033510)

Short name: PLAA/Doa1/Lub1

Overlapping homologous superfamilies


Family relationships



This entry includes PLAA from animals, Doa1 from budding yeasts and Lub1 from fission yeasts. Doa1 and Lub1 are involved in ubiquitin (Ub) homeostasis [PMID: 14993272, PMID: 7615550]. However, Lub1 appears to provide Ub specifically for proteasome-mediated protein degradation, whereas Doa1 recycles Ub from proteosomal degradation pathways into pathways that control chromatin structure and replication [PMID: 16705165]. Human PLAP may have a role in regulating phospholipase A2 activity [PMID: 9931468].

GO terms

Biological Process

GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Molecular Function

GO:0043130 ubiquitin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.