E3 ubiquitin-protein ligase RNF146 (IPR033509)

Short name: RNF146

Overlapping homologous superfamilies

Family relationships



RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling [PMID: 21478859]. It contains an N-terminal RING domain followed by a WWE domain that binds iso-ADPr. RNF146 is a RING E3 ligase whoes activities are regulated by non-covalent ligand binding [PMID: 25327252].

GO terms

Biological Process

GO:0016055 Wnt signaling pathway

Molecular Function

GO:0072572 poly-ADP-D-ribose binding
GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.