Family

Aminopeptidase A (IPR033508)

Short name: Aminopeptidase_A

Overlapping homologous superfamilies

None.

Family relationships

Description

Aminopeptidase A (or glutamyl aminopeptidase, (EC:3.4.11.7); MEROPS identifier M01.003) is an aminopeptidase that releases Glu and Asp residues from the N-termini of proteins and peptides [PMID: 13899213]. Although broadly distributed, the enzyme is particularly abundant in the brush borders of intestinal enterocytes and kidney [PMID: 8146860]. The enzyme is activated by calcium and inhibited by metal chelators [PMID: 7011318, PMID: 7448199]. Aminopeptidase A converts angiotensin II to angiotensin III, but in vivo conversion has only been shown in the brain [PMID: 8876246]. However, angiotensin III is a major effector peptide in control of vasopressin release and therefore control of blood pressure [PMID: 15136730]. This has led to the development of therapeutic agents for the control of hypertension, such as the orally administered RB150, which is an aminopeptidase A inhibitor [PMID: 18362226]. Aminopeptidase A is also abundantly expressed in the placenta and may have a role in preventing angiotensin II passing between mother and foetus [PMID: 10985964]. In the kidney, monoclonal antibodies to aminopeptidase A induce albuminuria [PMID: 1740657].

GO terms

Biological Process

GO:0002003 angiotensin maturation

Molecular Function

GO:0070006 metalloaminopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER