Pathways & interactions
UfSP1 peptidase (IPR033502)
Short name: UfSP1
Overlapping homologous superfamilies
- Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 (IPR012462)
- UfSP1 peptidase (IPR033502)
The UfSP1 peptidase (Ufm1-specific protease 1; MEROPS identifier C78.001) is a deubiquitinase-like enzyme that releases a ubiquitin-like protein known as ubiquitin-fold modifier 1 (Ufm1) from its isopeptide attachments to tagged proteins [PMID: 20018847, PMID: 17182609] and releases Ufm1 from its precursor [PMID: 17182609]. Ufm1 is structurally similar to ubiquitin, despite the sequence difference, and like ubiquitin is able to form isopeptide bonds via its C-terminal glycine to lysine side chains of target proteins [PMID: 15071506]. However, UfSP1 does not release ubiquitin or SUMO from tagged proteins [PMID: 17182609]. UfSP1 is structurally related to papain and has a similar catalytic triad consisting of Cys, Asp and His [PMID: 18321862] and is similarly inhibited by sulfhydryl-blocking agents such as N-ethylmaleimide [PMID: 17182609].
- PTHR44770 (PTHR44770)