UfSP1 peptidase (IPR033502)

Short name: UfSP1

Overlapping homologous superfamilies


Family relationships


The UfSP1 peptidase (Ufm1-specific protease 1; MEROPS identifier C78.001) is a deubiquitinase-like enzyme that releases a ubiquitin-like protein known as ubiquitin-fold modifier 1 (Ufm1) from its isopeptide attachments to tagged proteins [PMID: 20018847, PMID: 17182609] and releases Ufm1 from its precursor [PMID: 17182609]. Ufm1 is structurally similar to ubiquitin, despite the sequence difference, and like ubiquitin is able to form isopeptide bonds via its C-terminal glycine to lysine side chains of target proteins [PMID: 15071506]. However, UfSP1 does not release ubiquitin or SUMO from tagged proteins [PMID: 17182609]. UfSP1 is structurally related to papain and has a similar catalytic triad consisting of Cys, Asp and His [PMID: 18321862] and is similarly inhibited by sulfhydryl-blocking agents such as N-ethylmaleimide [PMID: 17182609].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0071567 UFM1 hydrolase activity
GO:0008234 cysteine-type peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.