Trinucleotide repeat-containing gene 6C protein (IPR033499)

Short name: TNRC6C

Overlapping homologous superfamilies


Family relationships



Mammals have three GW182 paralogues, TNRC6A, TNRC6B and TNRC6C. They interact directly with Argonaute (Ago) proteins and function downstream as effectors mediating mRNA repression. They repress mRNAs by recruiting the CCR4-NOT complex to the mRNA. They contain the N-terminal effector domain (NED), the middle Q-rich region, and the C-terminal effector domain (CED) containing the poly(A) binding protein (PABP)-interacting motif 2 (PAM2) and the RNA-recognition motif (RRM) [PMID: 21984184].

This entry represents TNRC6C from vertebrates. Similar to TNRC6A/B, TNRC6C is essential for efficient miRNA repression [PMID: 19304925].

GO terms

Biological Process

GO:0035278 miRNA mediated inhibition of translation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.