NUDE family (IPR033494)

Short name: NUDE

Overlapping homologous superfamilies


Family relationships


This entry includes nuclear distribution element 1 (NDE1) and NDE-like 1 (NDEL1). Human NDE1 and NDEL1 are believed to be evolved from a common ancestral gene, such as the NudE gene of Aspergillus nidulans. They share protein sequence and structure similarities and have overlapping functions in the cell and developing brain. They are essential for mitosis and neurodevelopment [PMID: 22843697]. They both interact with LIS1 through their N-terminal domain, and this interaction stimulates the movement of dynein. However, their expression and post-translational modification within the cell are different [PMID: 24093049]. This entry also includes Emericella nidulans NUDE, which acts in the cytoplasmic dynein/dynactin pathway and is required for distribution of nuclei [PMID: 11509576].

GO terms

Biological Process

GO:2000574 regulation of microtubule motor activity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.