Probable E3 ubiquitin-protein ligase MID2 (IPR033491)

Short name: MID2

Family relationships



MID2 shares high structural and functional similarities with MID1, an ubiquitin E3 ligase that regulates the turnover of microtubular protein phosphatase 2Ac. MID2 interacts with Astrin (a microtubule-organizing protein) and regulates Astrin levels to promote cell division [PMID: 26748699]. MID1 and MID2 may play roles in regulating tissue remodelling in early development [PMID: 26788540].

Mutations in the MID2 gene cause mental retardation, X-linked 101 (MRX101) [PMID: 24115387].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.