E3 ubiquitin-protein ligase RBBP6 family (IPR033489)

Short name: RBBP6

Overlapping homologous superfamilies


Family relationships



RBBP6 interacts with both p53 and pRb and has been implicated in mRNA processing [PMID: 25319826]. It also acts as a E3 ubiquitin-protein ligase that interacts with YB-1 and ZBTB38, leading to ubiquitination of both proteins [PMID: 18851979, PMID: 24726359]. It is involved in regulating DNA replication and common fragile site stability [PMID: 24726359].

This family also includes the homologues from yeast Mpe1 [PMID: 25135474] and PARAQUAT TOLERANCE3 from Arabidopsis [PMID: 27676073].

GO terms

Biological Process

GO:0006397 mRNA processing
GO:0016567 protein ubiquitination

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.