Conserved Site

Cornichon, conserved site (IPR033466)

Short name: Cornichon_conserved

Description

The drosophila cornichon protein (gene: cni), the founding member of this family, is an integral component of the COPII-coated vesicles that mediate cargo export from the yeast endoplasmic reticulum (ER) [PMID: 16396907]. It is required in the germline for dorsal-ventral signalling. The dorsal-ventral pattern formation involves a reorganisation of the microtubule network correlated with the movement of the oocyte nucleus, and depending on the initial correct establishment of the anterior-posterior axis via a signal from the oocyte produced by cornichon and gurken and received by torpedo protein in the follicle cells [PMID: 7540118].

This entry represents a conserved region located in the loop between the first and second transmembrane regions. This conserved region contains three acidic residues.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns