Family

Small kinetochore-associated protein (IPR033373)

Short name: SKAP

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Small kinetochore associated protein (SKAP) cooperates with kinetochore and mitotic spindle proteins to regulate the metaphase-to-anaphase transition [PMID: 12058064, PMID: 19667759]. Its interaction with astrin in the kinetochore is important for normal spindle architecture and chromosome alignment [PMID: 20937697, PMID: 21402792]. It interacts with MIS13 to orchestrate accurate interaction between kinetochore and dynamic spindle microtubules [PMID: 23035123]. It also interacts with mitotic motor CENP-E to orchestrate accurate chromosome segregation in mitosis [PMID: 22110139]. SKAP may also promote UV-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19 [PMID: 24718257].

GO terms

Biological Process

GO:0007059 chromosome segregation
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0007051 spindle organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000776 kinetochore

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER