Family

Protein BTG2 (IPR033328)

Short name: BTG2

Overlapping homologous superfamilies

Family relationships

None.

Description

BTG2 is a member of the BTG/Tob family. It plays an important role in cellular differentiation and cancer. It is a direct transcriptional target of p53 and has been shown to be a major effector of suppression of Ras-induced transformation by p53 [PMID: 16418486]. BTG2 has been shown to function as a transcription cofactor [PMID: 10617598]. BTG2 is also found to interact directly with the first RRM domain of the poly(A)-binding protein PABPC1 and promoted mRNA poly(A) tail shortening [PMID: 26912148]. In mice, its overexpression during neurogenesis led to microcephaly, while its deletion triggered impaired neuronal differentiation [PMID: 26912148].

The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation [PMID: 19746446].

GO terms

Biological Process

GO:0008285 negative regulation of cell population proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER