Nectin-2 (IPR033318)

Short name: Nectin-2

Overlapping homologous superfamilies


Family relationships



Nectins are single-pass type I membrane glycoproteins belonging to the immunoglobulin superfamily. They are characterised by three Ig-like domains (a distal IgV domain and two IgC domains) in the ectodomain, followed by a transmembrane region and a cytoplasmic tail [PMID: 18593353]. Unlike cadherins, nectins are Ca2+-independent cell adhesion molecules that mediate not only homotypic but also heterotypic cell-cell adhesion [PMID: 25733141]. The cytoplasmic tail of nectins possesses a conserved afadin-binding motif, except for nectin-4 which binds the PDZ domain of afadin at its carboxyl terminus. Afadin connects nectins to F-actin and the actin cytoskeleton [PMID: 9334353, PMID: 10225955, PMID: 18593353].

This entry represents nectin-2. Nectin-2 and nectin-3 are expressed in Sertoli cells and spermatids, respectively, and their heterophilic transinteraction regulates the organization of the Sertoli cell-spermatid junctions [PMID: 12121624]. Loss of nectin-2 leads to male infertility [PMID: 12801998, PMID: 10733589]. Nectin-2 is a receptor for Herpes simplex virus into cells [PMID: 11602758].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0007286 spermatid development
GO:0019062 virion attachment to host cell

Molecular Function

GO:0050839 cell adhesion molecule binding
GO:0042803 protein homodimerization activity

Cellular Component

GO:0005911 cell-cell junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.