Erlin1/2 (IPR033294)

Short name: Erlin1/2

Family relationships



This entry includes Erlin1/2 (also known as SPFH1/2) from animals and their homologues from plants. Mammalian Erlin1 and Erlin2 form a complex that mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 [PMID: 19240031, PMID: 17502376, PMID: 19751772]. The Erlin1/2 complex may recruit RNF170 (an E3 ubiquitin-protein ligase) to activated IP(3) receptors where it mediates IP(3) receptor ubiquitination [PMID: 21610068].

GO terms

Biological Process

GO:0030433 ubiquitin-dependent ERAD pathway

Molecular Function

GO:0031625 ubiquitin protein ligase binding

Cellular Component

GO:0005783 endoplasmic reticulum

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.