E3 ubiquitin-protein ligase MARCH-like (IPR033275)

Short name: MARCH-like

Overlapping homologous superfamilies


Family relationships


This entry includes human E3 ubiquitin-protein ligase MARCH proteins (MARCH1/2/3/4/5/8/9/11), and virus proteins (MIR1, MIR2, LAP and VIE1) that share homology with the MARCH proteins [PMID: 14722266, PMID: 12582153].

Human MARCH1 mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies [PMID: 18389477]. Virus MIR1 has been shown to function as an E3 ubiquitin ligase for immune recognition-related molecules [PMID: 11756476].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.