Family

Signaling threshold-regulating transmembrane adapter 1 (IPR033269)

Short name: Sit1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

SIT (or Sit1) is a transmembrane adapter protein that negatively regulates signalling from the T-cell receptor (TCR) [PMID: 10209036, PMID: 16107703, PMID: 18209059]. SIT regulates T cell development and peripheral homeostasis.

GO terms

Biological Process

GO:0043029 T cell homeostasis
GO:0050863 regulation of T cell activation
GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
ProDom