Family

EP300-interacting inhibitor of differentiation 1 (IPR033255)

Short name: EID-1

Overlapping homologous superfamilies

None.

Family relationships

Description

EP300-interacting inhibitor of differentiation 1 (EID-1) is a nuclear protein that blocks the differentiation of skeletal muscle. It interacts with p300 and the retinoblastoma protein (Rb), and represses the transcriptional activity of MyoD. Inhibition of MyoD is linked to EID-1's ability to inhibit p300's histone acetylase activity, an essential MyoD coactivator [PMID: 11073990]. EID-1 is rapidly degraded by the proteasome as cells exit the cell cycle [PMID: 11073989]. EID-1 is also a corepressor of orphan nuclear receptor SF-1 transactivation [PMID: 18182853].

GO terms

Biological Process

GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045595 regulation of cell differentiation
GO:0035065 regulation of histone acetylation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER