Family

Tyrosine-protein kinase ABL1/transforming protein Abl (IPR033221)

Short name: ABL1

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry includes animal ABL1 and viral oncogene products that are homologous to ABL1 [PMID: 6191223]. ABL1 plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodelling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis [PMID: 17623672, PMID: 16943190, PMID: 11971963, PMID: 18945674]. Normal ABL1 can serve as a tumour suppressor and therapeutic target in leukemias expressing oncogenic forms of the kinase [PMID: 26864341].

ABL tyrosine kinases are nonreceptor tyrosine kinases containing an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity. This cassette is coupled to an actin-binding and -bundling domain, which makes ABL proteins capable of connecting phosphoregulation with actin-filament reorganization. Two vertebrate ABL tyrosine kinases have been identified, ABL1 and ABL2 [PMID: 20841568]. A downstream effector of RAS, RIN1, have been found to bind to the SH3 and SH2 domains of ABL1/ABL2 to relieve autoinhibition and regulate their activity [PMID: 18796434].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004713 protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER