Vitamin K-dependent protein S (IPR033189)

Short name: PROS1

Overlapping homologous superfamilies

Family relationships



Vitamin K-dependent protein S (PROS1 or protein S) is an essential anticoagulant and multifunctional protein. It serves as a cofactor to activated protein C (APC) in the proteolytic inactivation of potent coagulation factors (F) Va and VIIIa [PMID: 19809585].

Mutations in the PROS1 gene cause THPH5 (thrombophilia due to protein S deficiency, autosomal dominant), a hemostatic disorder characterised by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis [PMID: 7482398, PMID: 7803790].

GO terms

Biological Process

GO:0030195 negative regulation of blood coagulation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.