Signal peptide peptidase-like 2a (IPR033151)

Short name: SPPL2a

Overlapping homologous superfamilies


Family relationships


Signal peptide peptidase-like 2a (MEROPS identifier A22.007) is an intramembrane peptidase that performs regulated intramembrane proteolysis, particularly on single pass type II transmembrane proteins. It is predominantly localized to late endosomes and lysosomes because of a C-terminal tyrosine motif [PMID: 21896273]. SPPL2a cleaves the N-terminal fragment of the invariant chain, and is essential for B-cell development [PMID: 23267013]. The membrane stump, following shedding of the ectodomain, of frontotemporal lobar degeneration risk factor TMEM106B is also a substrate [PMID: 24872421].

GO terms

Biological Process

GO:0031293 membrane protein intracellular domain proteolysis
GO:0050776 regulation of immune response

Molecular Function

GO:0042500 aspartic endopeptidase activity, intramembrane cleaving

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.