PTM

Neuromodulin, phosphorylation site (IPR033137)

Short name: Neuromodulin_P_site

Description

Neuromodulin (also known as GAP-43, pp46, B-50, F1, and P-57) [PMID: 2648946] is an axonal membrane protein associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Neuromodulin is an hydrophilic protein of 210 to 240 amino acid residues, which binds calmodulin and inhibits phosphatidylinositol phosphate kinase (PIP kinase). It is phosphorylated by protein kinase C, and regulates the binding of GTP to G(0) [PMID: 2158629]. Neuromodulin contains an IQ motif.

This entry represents a conserved region containing a serine residue which can be phosphorylated by protein kinase C [PMID: 2140056] and which is adjacent to the calmodulin-binding domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns