Cleavage stimulation factor subunit 2 (IPR033105)

Short name: CSTF2

Overlapping homologous superfamilies


Family relationships



Cleavage stimulation factor subunit 2 (CSTF2, also known as CstF-64) is a member of cleavage stimulation factor complex (CSTF), which is necessary for efficient and accurate polyadenylation of most mRNAs. It is necessary for correct histone mRNA 3' end processing as well as maintenance of pluripotency in mouse embryonic stem cells [PMID: 25460602]. In response to epidermal growth factor (EGF), it serves as a major regulator of 3'UTR shortening [PMID: 26395459].

GO terms

Biological Process

GO:0031124 mRNA 3'-end processing
GO:0006378 mRNA polyadenylation

Molecular Function

GO:0003723 RNA binding

Cellular Component

GO:0005847 mRNA cleavage and polyadenylation specificity factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.