Negative elongation factor E (IPR033102)

Short name: NELFE

Overlapping homologous superfamilies


Family relationships



Negative elongation factor E (NELFE) is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II [PMID: 10199401]. The NELF complex is found in higher eukaryotes, but is absent in some species of nematodes, S. cerevisiae, and plants. It may repress transcription by inducing transcriptional pausing [PMID: 23202475] and can be regulated by integrator complex subunits (INTScom) [PMID: 25410209].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0032021 NELF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.