Interleukin enhancer-binding factor 3 (IPR033099)

Short name: ILF3/NF90

Overlapping homologous superfamilies


Family relationships



The alternative splicing of the ILF3 gene generates two ubiquitous proteins, interleukin enhancer binding factor 3 (Ilf3) and Nuclear Factor 90 (NF90). They have an identical N-terminal domain of 701 amino acids and a specific C-terminal domain of 210 and 15 amino acids, respectively. They are double-stranded RNA-binding proteins implicated in mRNA metabolism [PMID: 23321469].

NF90 and its isoforms are involved in transcription, translation, mRNA export and microRNA biogenesis. They are involved in DNA and RNA virus replication [PMID: 25447144].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003725 double-stranded RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.