RNA-binding protein Nova-2 (IPR033087)

Short name: Nova-2

Overlapping homologous superfamilies


Family relationships



Nova-2 is a neuron-specific splicing factor that binds to specific pre-mRNA [PMID: 12808107, PMID: 9789075]. It regulates the alternative pre-mRNA splicing in N-type and P-type CaV2 calcium channels [PMID: 21150296].

Nova proteins, including Nova-1 and Nova-2, are implicated in paraneoplastic opsoclonus-myoclonus-ataxia (POMA) syndrome. They were the first mammalian neuron-specific splicing factors identified. Nova-1 is expressed in the subcortical CNS structures in developing and adult mice, while Nova-2 is expressed throughout the CNS and particularly in cortex, olfactory bulb, thalamus, inferior colliculus, etc. They harbour three K-homology (KH) motifs that mediate Nova binding to clusters of YCAY motifs on target pre-mRNAs [PMID: 21150296, PMID: 21742260].

GO terms

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.