CD36 (IPR033076)

Short name: CD36_chordates

Overlapping homologous superfamilies


Family relationships


CD36 (also known as platelet glycoprotein 4) is a recognition receptor that binds polyanionic ligands of both pathogen and self-origin, and is implicated in the pathogenesis of atherosclerosis and Alzheimer's disease [PMID: 23812099, PMID: 24903227]. CD36 plays an important role in innate immunity and in the phagocytic uptake of multiple pathogens including malaria [PMID: 25113859]. It has also been implicated in several aspects related to fatty acid metabolism [PMID: 24850384].

Mutations in the CD36 gene cause platelet glycoprotein IV deficiency (PG4D), a disorder characterised by macrothrombocytopenia without notable hemostatic problems and bleeding tendency [PMID: 7533783, PMID: 11950861].

GO terms

Biological Process

GO:0007166 cell surface receptor signaling pathway
GO:0006955 immune response

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.