Fatty acid-binding protein 4 (IPR033073)

Short name: FABP4

Overlapping homologous superfamilies

Family relationships


Fatty acid-binding proteins (FABPs) have been designated according to the first tissue they were isolated from: intestinal (I-FABP), liver (L-FABP), adipocyte(A-FABP), heart (H-FABP), ileal, myelin, brain, epidermal, and sperm. However, each of these FABPs may be expressed in more than one tissue.

Fatty acid-binding protein 4 (FABP4) is an adipose tissue-secreted adipokine implicated in the regulation of energetic metabolism and inflammation [PMID: 25037742]. It is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation [PMID: 25674026]. FABP4 can reversibly bind to fatty acids and other lipids with high affinities [PMID: 26580122].

GO terms

Biological Process

GO:0050727 regulation of inflammatory response

Molecular Function

GO:0005504 fatty acid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.