Pathways & interactions
ETS-related transcription factor Elf-4 (IPR033070)
Short name: Elf4
Overlapping homologous superfamilies
- Winged helix-like DNA-binding domain superfamily (IPR036388)
Elf4 or MEF (myeloid Elf-1-like factor) is an ETS transcription factor that activates innate immunity-associated genes such as lysozyme [PMID: 10400620], human beta-defensin 2 [PMID: 15013761], interleukin-8 (IL-8) [PMID: 14625302], and type I interferon [PMID: 24658434]. It plays a role in the development and function of natural killer and NK T-cells [PMID: 12387738]. Elf4/MAF has oncogenic properties and contributes to malignant transformation by inhibiting both the p53 and p16/Rb pathways [PMID: 17213815, PMID: 19380490]. It also promotes the transition of cells from G1 to S phase and enhances the movement of hemapotoietic stem cells out of a quiescent state (G0 phase) into the cell cycle [PMID: 16530702, PMID: 19128791].
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
No terms assigned in this category.
- PTHR11849:SF170 (PTHR11849:SF170)