ETS-related transcription factor Elf-4 (IPR033070)

Short name: Elf4

Overlapping homologous superfamilies

Family relationships



Elf4 or MEF (myeloid Elf-1-like factor) is an ETS transcription factor that activates innate immunity-associated genes such as lysozyme [PMID: 10400620], human beta-defensin 2 [PMID: 15013761], interleukin-8 (IL-8) [PMID: 14625302], and type I interferon [PMID: 24658434]. It plays a role in the development and function of natural killer and NK T-cells [PMID: 12387738]. Elf4/MAF has oncogenic properties and contributes to malignant transformation by inhibiting both the p53 and p16/Rb pathways [PMID: 17213815, PMID: 19380490]. It also promotes the transition of cells from G1 to S phase and enhances the movement of hemapotoietic stem cells out of a quiescent state (G0 phase) into the cell cycle [PMID: 16530702, PMID: 19128791].

GO terms

Biological Process

GO:0001866 NK T cell proliferation
GO:0045087 innate immune response
GO:0001787 natural killer cell proliferation
GO:0045944 positive regulation of transcription by RNA polymerase II

Molecular Function

GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.