Family

Retinoblastoma-associated protein (IPR033057)

Short name: RB1

Overlapping homologous superfamilies

None.

Family relationships

Description

Retinoblastoma-associated protein (RB1, also known as RB) regulates cell proliferation through the transcriptional repression of genes involved in cellular G1 to S phase transition. It interacts with the E2F1/DP1 complex and represses E2F/DP-mediated transcriptional activation. This interaction can be impeded by Cyclin-Cdk phosphorylation leading to activated transcription [PMID: 26319102]. Eliminating RB function has been shown to allow unregulated cell cycle progression and promotes tumour growth. RB also plays roles in the cell cycle, maintenance of genome stability and apoptosis [PMID: 23594950].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated

Molecular Function

GO:0008134 transcription factor binding

Cellular Component

GO:0035189 Rb-E2F complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER