POU domain, class 6, transcription factor 2 (IPR033056)

Short name: POU6F2

Overlapping homologous superfamilies


Family relationships



POU6F2, also known as retina-derived POU domain factor 1 (RPF1), is a transcription factor and a tumour suppressor associated with Wilms tumor (WT), a kidney malignancy of childhood characterised by highly heterogeneous genetic alterations [PMID: 17164647, PMID: 15459955]. In zebrafish it is involved retina regeneration [PMID: 25190811]. It has been shown to be involved in pituitary development [PMID: 24804940].

GO terms

Biological Process

GO:0007275 multicellular organism development
GO:0006366 transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.