Domain

FAS-associated factor 1, UBX domain (IPR033043)

Short name: FAF1_UBX

Overlapping homologous superfamilies

None.

Domain relationships

  • UBX domain (IPR001012)
    • FAS-associated factor 1, UBX domain (IPR033043)

Description

FAS-associated factor 1 (FAF1) is a multidomain protein involved in various biological processes, including regulation of apoptosis and NFkappaB activity, and ubiquitination and proteasomal degradation [PMID: 19597341]. It has been linked to cancer, asbestos-induced mesotheliomas, and Parkinson's disease [PMID: 19722279]. FAF1 contains multiple ubiquitin-related domains, including ubiquitin-associated (UBA), ubiquitin-like 1 and 2 (UBL1, UBL2), and ubiquitin regulatory X (UBX) domains. FAF1 interacts with polyubiquitinated proteins via its N-terminal UBA domain and with valosin containing protein (VCP) via its C-terminal UBX domain [PMID: 15743842, PMID: 23293021, PMID: 22876279].

This entry represents the UBX domain. The UBX domain has a beta-grasp fold similar to that of ubiquitin; however, UBX lacks the C-terminal double glycine motif and is thus unlikely to be conjugated to other proteins.

GO terms

Biological Process

GO:0008219 cell death

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD