Atypical chemokine receptor 2 (IPR033037)

Short name: Ackr2

Overlapping homologous superfamilies


Family relationships


Atypical chemokine receptor 2 (ACKR2/D6) [PMID: 19130487], previously known as CCR9 or CCR10 [PMID: 26097478], is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [PMID: 12594248, PMID: 15004236]. ACKR2 is highly promiscuous and can bind the majority of (if not all) inflammatory CC-chemokines [PMID: 26097478]. It plays an essential role in the resolution of the inflammatory response [PMID: 23479571, PMID: 15750596, PMID: 23125030]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signalling pathways downstream of ligand binding [PMID: 23633677]. It has been shown to be involved in regulating vessel density [PMID: 25271254].

GO terms

Biological Process

GO:0006954 inflammatory response

Molecular Function

GO:0019957 C-C chemokine binding
GO:0005044 scavenger receptor activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.