Palladin, C-terminal immunoglobulin-like domain (IPR033017)

Short name: Palladin_C

Overlapping homologous superfamilies

Domain relationships



Palladin is a cytoskeletal actin scaffold protein that regulates actin dynamics. The immunoglobulin-like domain of palladin is directly responsible for both actin binding and bundling [PMID: 18180288, PMID: 23806659]. Palladin also interacts with different actin binding proteins and signalling intermediaries required for regulation of cytoskeleton organisation, including profilin [PMID: 16367745], VASP [PMID: 14983521], Eps8 [PMID: 16868024], ezrin [PMID: 11598191], Lasp-1 [PMID: 16492705], and Src [PMID: 17537434]. Palladin plays an important role in smooth and skeletal muscle differentiation [PMID: 20877641, PMID: 25875253, PMID: 25194811], contraction [PMID: 19015263] and cell migration [PMID: 15950489, PMID: 25194811, PMID: 20471940].

Palladin is expressed as several alternatively spliced isoforms, having various combinations of Ig-like domains, in a cell-type-specific manner. It has been suggested that palladin's different Ig-like domains may be specialized for distinct functions [PMID: 18180288]. This entry represents the C-terminal immunoglobulin-like domain (Ig5).

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization
GO:0016477 cell migration

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.