Family

Netrin receptor DCC (IPR033012)

Short name: DCC

Overlapping homologous superfamilies

Family relationships

None.

Description

DCC (deleted in colorectal cancer) is a receptor for netrin required for axon guidance [PMID: 8861902, PMID: 11239160]. It also binds a second axon guidance protein, Draxin [PMID: 21957262]. The interactions between these guidance cues and DCC play a key role in the development of the nervous system.

DCC belongs to the immunoglobulin superfamily. The protein consists of four N-terminal Ig-like domains [PMID: 23038776] followed by six fibronectin type III domains (FN), a transmembrane segment and the cytosolic portion [PMID: 8861902]. The deletion of DCC has been linked to the propensity of cancerous cells to metastasise [PMID: 22358843, PMID: 8187090]. DCC indeed functions as a tumour suppressor through its ability to trigger tumour cell apoptosis [PMID: 22158121].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0007411 axon guidance
GO:0007399 nervous system development

Molecular Function

GO:0005042 netrin receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER