COP9 signalosome complex subunit 1 (IPR033008)

Short name: CSN1

Overlapping homologous superfamilies


Family relationships


COP9 signalosome complex subunit 1 (CSN1) is an essential component of the COP9 signalosome complex (CSN), an eight-subunit protein complex that is found in all eukaryotes [PMID: 19141280]. The CSN complex cleaves the isopeptide bond of ubiquitin-like protein Nedd8 from cullins and is involved in various cellular and developmental processes, such as repression of photomorphogenesis in plants and protein subcellular localization, DNA-damage response, and NF-kappaB activation in mammals [PMID: 26497135, PMID: 23818606]. CSN1 carries a C-terminal PCI (for Proteasome, COP9 signalosome, and Initiation factor 3) domain which mediates protein-protein interactions within the complex [PMID: 18854373]. Its N-terminal domain is critical for the function of CSN [PMID: 22133685].

GO terms

Biological Process

GO:0000338 protein deneddylation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0008180 COP9 signalosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.