Family

Roundabout homologue 1 (IPR032986)

Short name: Robo1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The secreted Slit repellents and their Roundabout (Robo) receptors were originally identified as important axon guidance molecules. The SLIT-ROBO interaction has been found to be involved in the regulation of cell migration, cell death and angiogenesis and, as such, has a pivotal role during the development of other tissues such as the lung, kidney, liver and breast [PMID: 20100881]. There are four Robo homologues in vertebrates (Robo1-4).

Robo1 and Robo2 are known to play a crucial role in axon guidance [PMID: 15091338, PMID: 17360927]. They overlap to cooperate in guiding longitudinal axons, but each isoform has specialised functions in spinal commissural axon guidance [PMID: 21820427, PMID: 20631173]. Robo1 prevents axonal stalling after crossing [PMID: 20631173]. Robo1 may also be involved in lung [PMID: 11734623] and heart development [PMID: 20941780, PMID: 25691540].

Deregulation of Robo is implicated in several neuropathological conditions and cancers [PMID: 22588058].

GO terms

Biological Process

GO:0035385 Roundabout signaling pathway
GO:0007411 axon guidance
GO:0007507 heart development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER