Protein-cysteine N-palmitoyltransferase HHAT (IPR032981)
Short name: HHAT
Overlapping homologous superfamilies
- Membrane bound O-acyl transferase, MBOAT (IPR004299)
- Protein-cysteine N-palmitoyltransferase HHAT (IPR032981)
Protein-cysteine N-palmitoyltransferase, also known as hedgehog acyltransferase (HHAT), catalyses the N-terminal palmitoylation of Sonic hedgehog (Shh) [PMID: 9593755, PMID: 15075292, PMID: 18534984]. Shh is a signaling molecule involved in embryonic patterning and organogenesis, and these lipid modifications serve to regulate its movement to form the proper concentration gradient. Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers, thus HHAT inhibition is considered a target for tumour growth suppression [PMID: 24608521].
HHAT is a multipass transmembrane enzyme with a membrane-bound O-acyltransferase (MBOAT) homology domain [PMID: 25488661].
- PTHR13285:SF20 (PTHR13285:SF20)