Protein-cysteine N-palmitoyltransferase HHAT (IPR032981)

Short name: HHAT

Overlapping homologous superfamilies


Family relationships


Protein-cysteine N-palmitoyltransferase, also known as hedgehog acyltransferase (HHAT), catalyses the N-terminal palmitoylation of Sonic hedgehog (Shh) [PMID: 9593755, PMID: 15075292, PMID: 18534984]. Shh is a signaling molecule involved in embryonic patterning and organogenesis, and these lipid modifications serve to regulate its movement to form the proper concentration gradient. Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers, thus HHAT inhibition is considered a target for tumour growth suppression [PMID: 24608521].

HHAT is a multipass transmembrane enzyme with a membrane-bound O-acyltransferase (MBOAT) homology domain [PMID: 25488661].

GO terms

Biological Process

GO:0018345 protein palmitoylation
GO:0007224 smoothened signaling pathway

Molecular Function

GO:0016409 palmitoyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.