Protein unc-119 homologue A-like (IPR032977)

Short name: UNC119_homologue_A

Overlapping homologous superfamilies

Family relationships



This entry represents protein unc-119 homologue A (UNC119) from vertebrates, also known as retinal protein 4 (RG4) [PMID: 9538874], and the homologue from Drosophila [PMID: 10858820]. It is highly expressed in retinal photoreceptor inner segments and synaptic regions. Nevertheless, UNC119 has been detected in leukocytes (eosinophils), T-cells, lung fibroblasts, the adrenal glands, cerebellum and kidney. It interacts with several diverse proteins, such as Arf-like GTPases ARL2/ARL3 [PMID: 12527357, PMID: 18588884] and the Ca2+-binding protein CaBP4 [PMID: 18296658]. It has been shown to activate Src-type tyrosine kinases associated with the interleukin-5 receptor and the T-cell receptor. It is also required for G protein trafficking in sensory neurons [PMID: 21642972].

Mutations in the UNC119 gene cause immunodeficiency 13 (IMD13), a rare and heterogeneous syndrome defined by a reproducible reduction in the CD4 T-lymphocyte count [PMID: 22184408].

GO terms

Biological Process

GO:0007399 nervous system development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.