Retinal homeobox protein Rx-like (IPR032967)

Short name: Rx-like

Overlapping homologous superfamilies


Family relationships



RX is a homeodomain-containing protein essential for proper eye development [PMID: 10625658] and for retinal regeneration [PMID: 21334323]. It binds to the photoreceptor conserved element-1 (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter and stimulates gene expression [PMID: 10625658]. Interestingly, transduction of a combination of CRX, RX and NEUROD induces all of the opsin genes: blue opsin, green/red opsin and rhodopsin [PMID: 22558175].

This family also includes the orthologous homeobox protein Ceh-8 from C. elegans.

GO terms

Biological Process

GO:0006366 transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.