Transforming growth factor-beta-induced protein ig-h3 (IPR032954)

Short name: TGFBI

Overlapping homologous superfamilies

Family relationships


The TGFBI (transforming growth factor-beta-induced protein ig-h3) gene was originally identified as a gene induced by transforming growth factor-beta stimulation in adenocarcinoma cells. Later, it was found to interact with a number of extracellular matrix (ECM) proteins, including fibronectin, biglycan, decorin, and several types of collagen. It also acts as a ligand for several integrins, including alhpa3beta1, alphavbeta5, alphavbeta3, and alphambeta2. It may function as a secreted factor involved in cell adhesion, proliferation, and migration [PMID: 19478074].

Mutations in the TGFBI gene cause several types of corneal dystrophy [PMID: 16652336, PMID: 15623763, PMID: 11413411, PMID: 9780098, PMID: 9497262].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0008283 cell population proliferation

Molecular Function

GO:0005518 collagen binding
GO:0050840 extracellular matrix binding
GO:0005178 integrin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.