Homeobox protein SIX3 (IPR032949)

Short name: SIX3

Overlapping homologous superfamilies


Family relationships



SIX3 is a transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on target genes. During brain development, it maintains anterior forebrain identity and is required for neuroretinal specification and ependymal cell maturation [PMID: 22071110]. It is also involved in eye development [PMID: 12163408, PMID: 17066077] and pituitary development [PMID: 18694563].

The human SIX protein family consists of six members (SIX1-SIX6), all of which contain two protein domains: a DNA binding homeobox domain and a SIX domain, which binds downstream effector molecules. They are thought to be transcription factors required for proper eye development [PMID: 24875647].

GO terms

Biological Process

GO:0007420 brain development
GO:0001654 eye development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.