BPI/LBP/Plunc family (IPR032942)

Short name: BPI/LBP/Plunc

Overlapping homologous superfamilies


Family relationships


The BPI (bactericidal permeability-increasing proteins)/LBP (lipopolysaccharide-binding proteins)/PLUNC (palate, lung and nasal epithelium clone) family consists of proteins involved in host defence against bacteria, many acting in early recognition of bacteria in the upper respiratory tract [PMID: 15106612, PMID: 11971875, PMID: 12887310]. They share homology with cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP), both of which are involved in lipid transport in blood plasma [PMID: 12837268]. This entry also matches UPF0522 proteins from Dictyostelium (slime mold), whose function is unknown.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.