Mitogen-activated protein kinase kinase kinase MLT (IPR032938)

Short name: MLTK

Overlapping homologous superfamilies


Family relationships



Mitogen-activated protein kinase kinase kinase 20 (MLT or MLTK) has two alternatively spliced forms, MLTK-alpha and MLTK-beta. They both have identical amino acid sequences in the N-terminal region, while MLTK-alpha has a longer C-terminal region containing a sterile-alpha-motif (SAM). MLTK-alpha and MLTK-beta form homo- and heterodimers, and can be activated by osmotic stress. They can activate the p38 and JNK pathways through MKK3/6 and MKK4/7 phosphorylation. Xenopus laevis MLTK regulates chondrogenesis by inducing the transcription factor Sox6 [PMID: 22764049]. In rats MLTKalpha plays an essential role in the apoptosis of hippocampal CA1 neurons [PMID: 22146853].

GO terms

Biological Process

GO:0000186 activation of MAPKK activity

Molecular Function

GO:0004709 MAP kinase kinase kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.