Neuronal acetylcholine receptor subunit beta-2 (IPR032932)

Short name: CHRNB2

Overlapping homologous superfamilies

Family relationships


CHRNB2 is a subunit of the neuronal nicotinic acetylcholine receptor. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions [PMID: 22361591].

Acetylcholine receptors (AChRs) consist of two major subtypes: the metabotropic muscarinic receptors and the ionotropic nicotinic receptors (nAChRs). Both share the property of being activated by the neurotransmitter acetylcholine (ACh), and they are expressed by both neuronal and nonneuronal cells throughout the body [PMID: 19126755]. Multiple subunits have been identified for the nicotinic acetylcholine receptors (nAChRs). Mutations in CHRNB2 are associated with epilepsy [PMID: 15964197].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0022848 acetylcholine-gated cation-selective channel activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.