Erbin (IPR032927)

Short name: Erbin

Overlapping homologous superfamilies


Family relationships



Erbin (also known as Protein LAP2), was first identified as an adaptor for the receptor ERBB2/HER2 in epithelia [PMID: 10878805]. It is involved in inhibition of several intracellular signalling pathways, such as Ras-mediated activation of extracellular signal-regulated kinase (ERK), nuclear factor kappaB, and transforming growth factor beta signalling pathways [PMID: 24711380].

It contains an N-terminal domain with 16 leucine-rich repeats and a C-terminal PDZ domain. Through its amino-terminal region, Erbin disrupts Ras-Raf interaction by preventing the Ras-binding protein Shoc2 from binding to Ras, and thus acting as a tumour suppressor [PMID: 26056141].

GO terms

Biological Process

GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0007165 signal transduction

Molecular Function

GO:0005176 ErbB-2 class receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.