Tripartite motif-containing protein 5 (IPR032917)

Short name: TRIM5

Overlapping homologous superfamilies


Family relationships



Tripartite motif-containing protein 5 (TRIM5) is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus invasion of the target cell cytoplasm [PMID: 21512573]. It is a regulator of autophagy [PMID: 25127057].

Interestingly, while each primate species has a single TRIM5 gene, mice have at least seven TRIM5 homologues that cluster into two groups, Trim12a, -b, and -c and Trim30a, -b, -c, and -d. The three Trim12 proteins activated innate immune signaling, while the Trim30 proteins did not [PMID: 26468522].

GO terms

Biological Process

GO:0006914 autophagy
GO:0051607 defense response to virus
GO:0045087 innate immune response

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.